Fig. 5. Helios is more closely associated with disease activity than Foxp3 on CD4⁺CD25^hi T cells in RA patients. (a) The expression of Helios in CD4⁺CD25^hi T cells was similar to Foxp3 on RA Tregs (p>0.05). (b) The expression of Helios in CD4⁺CD25^hi T cells was negatively correlated with DAS28 score (r=-0.3277, p=0.0044) (left), while the expression of Foxp3 was not associated with DAS28 score on these T cells (p>0.05) (right). The p value was measured with Mann-Whitney test. Correlation analyses were carried out using Spearman's rank correlation test. n.s., not significant.